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Research Article
Analysis of Influencing Factors for Chronic Neck Pain with Cognitive Impairment
Ying Su*
Issue:
Volume 13, Issue 2, December 2025
Pages:
63-69
Received:
24 June 2025
Accepted:
7 July 2025
Published:
28 July 2025
Abstract: Background: Cervical spondylosis is a common chronic degenerative musculoskeletal disorder. It is based on the degeneration of the cervical intervertebral discs and secondary pathological changes, affecting the surrounding soft tissues, nerve roots, vertebral arteries, sympathetic nerves, and spinal cord. This condition gives rise to a series of clinical symptoms and signs. Pain represents one of the most crucial manifestations. Notably, when pain symptoms endure for over three months, this may give rise to chronic neck pain (CNP). The progression of this chronic neck pain may increase the risk of cognitive impairment (CI). However, to date, predictive markers for chronic neck pain with cognitive impairment (CNP-CI) remain lacking. Previous investigations have demonstrated that routine blood parameters possess predictive utility for Alzheimer's disease. However, the association between these parameters and chronic neck pain with CNP - CI remains elusive. This study was designed to explore the correlations among routine blood indices and to provide evidence regarding the differences between two groups of patients with chronic neck pain, namely those with and without cognitive impairment. Additionally, this study aims to lay the groundwork for longitudinal experimental investigations into effective intervention strategies for patients with chronic neck pain who develop cognitive impairment. Methods: This cross-sectional study was conducted in West China Hospital, Sichuan University. Montreal Cognitive Assessment (MoCA) was conducted to divide patients into the CNP-CI or CNP-nCI group. Statistical analysis was performed to examine the differences between chronic neck pain patients with cognitive impairment and those without cognitive impairment. All statistical tests were conducted at a significant level of α=0.05 for two-sided testing. Results: The prevalence of chronic neck pain with cognitive impairment in this study demonstrates age-related disparities, with a higher prevalence observed among older individuals (P=0.007). A statistically significant difference in serum calcium was observed between individuals with chronic neck pain and cognitive impairment (P=0.046). Conclusion: The age and serum calcium may serve as influential factors in the development of chronic neck pain with cognitive impairment. This finding can aid healthcare professionals in implementing early intervention and treatment for individuals experiencing this condition.
Abstract: Background: Cervical spondylosis is a common chronic degenerative musculoskeletal disorder. It is based on the degeneration of the cervical intervertebral discs and secondary pathological changes, affecting the surrounding soft tissues, nerve roots, vertebral arteries, sympathetic nerves, and spinal cord. This condition gives rise to a series of cl...
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Research Article
Comparative Evaluation of the Effects of Ephedrine and Phenylephrine on Neonatal Umbilical Cord Blood Gases
Issue:
Volume 13, Issue 2, December 2025
Pages:
70-75
Received:
5 June 2025
Accepted:
23 June 2025
Published:
4 August 2025
Abstract: Background: Ephedrine has commonly been regarded as the vasopressor of choice for treatment of hypotension in obstetrics, but there are concerns it causes neonatal acidosis.While some authors have recommended phenylephrine because it has not been associated with neonatal acidosis, others have found no difference between the two. Objective: To compare umbilical cord blood gases in neonates of parturients who received ephedrine and phenylephrine for prevention of maternal hypotension following subarachnoid block for caesarean section. Methods: Sixty-two neonates whose mothers received either ephedrine (group E) or phenylephrine (group P) during elective caesarean section were randomized in this double blind study into two groups each of 31.Umbilical arterial blood sample was collected and analysed immediately following delivery using an ABGmachine. Results: The mean umbilical artery pH was 7.30±0.05 and 7.31±0.02 for groups E and P respectively (p value=0.097). The mean PaCO2 (mmHg) was 44.44±4.01 and 46±3.95 for groups E and P respectively (p value=0.208). while the mean PaO2 (mmHg) was 25.85±3.14 and 27.40±1.76 for groups E and P respectively (p value=0.075). The mean HCO3-(mmHg) between the groups were 22.53±1.76 and 22.18±1.21 for groups E and P respectively (p value=0.205). Also, the mean base excess in groups E and P were -3.72±0.90 and -3.05±1.1 respectively (p value=0.054). There was no difference in the Apgar scores and maternal haemodynamic parameters in both groups. Conclusion:There was no difference in the umbilical cord gases and Apgar scores of neonates whose mothers received either ephedrine or phenylephrine.
Abstract: Background: Ephedrine has commonly been regarded as the vasopressor of choice for treatment of hypotension in obstetrics, but there are concerns it causes neonatal acidosis.While some authors have recommended phenylephrine because it has not been associated with neonatal acidosis, others have found no difference between the two. Objective: To compa...
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Research Article
Research Advances in the Biological Functions of RBM3
Long Feiyu*
Issue:
Volume 13, Issue 2, December 2025
Pages:
76-81
Received:
21 July 2025
Accepted:
31 July 2025
Published:
13 August 2025
Abstract: In clinical research, "hypothermia therapy" (at 32-34°C) has been proven to be an effective method for alleviating neurological deficits in neonatal hypoxic-ischemic encephalopathy and adult acute brain injury. Even deeper levels of hypothermia have been used in heart and transplant surgeries. However, "hypothermia therapy" in clinical settings cannot avoid many life-threatening side effects. Its effects go far beyond what was initially observed under hypothermic conditions. RNA-binding motif protein 3 (RBM3), a critical cold shock protein, has revealed significance extending far beyond its initial discovery in hypothermia. Induced by diverse stressors-notably mild hypothermia-RBM3 orchestrates complex post-transcriptional processes, modulating mRNA stability, translation, alternative splicing, and phase separation. It further regulates multiple cellular physiological processes, including neuroprotection, tumorigenesis, anti-apoptosis, and cell cycle progression. This review outlines RBM3’s structure and distribution in humans and synthesizes recent advances in understanding its multifaceted biological functions.
Abstract: In clinical research, "hypothermia therapy" (at 32-34°C) has been proven to be an effective method for alleviating neurological deficits in neonatal hypoxic-ischemic encephalopathy and adult acute brain injury. Even deeper levels of hypothermia have been used in heart and transplant surgeries. However, "hypothermia therapy" in clinical settings can...
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Review Article
Research Progress on Postoperative Analgesia After Total Hip Arthroplasty
Yang Chen,
Yang Jing*
Issue:
Volume 13, Issue 2, December 2025
Pages:
82-88
Received:
29 July 2025
Accepted:
7 August 2025
Published:
18 August 2025
DOI:
10.11648/j.ijacm.20251302.14
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Abstract: Total hip arthroplasty (THA) is a highly effective treatment for end-stage osteoarthritis and hip fractures, significantly enhancing patients' quality of life. However, substantial postoperative pain remains a challenge, potentially impeding rehabilitation, prolonging hospitalization, and increasing the risk of chronic pain and subsequent revision surgeries. Multimodal analgesia (MA), which combines two or more analgesic methods with different mechanisms, is commonly employed in clinical practice to manage postoperative pain in THA. Among these methods, regional nerve blocks and local infiltration analgesia (LIA) have gained increasing attention due to their excellent analgesic effects and relatively few adverse reactions. This article reviews the two primary analgesic methods for postoperative THA: regional nerve blocks, including the emerging pericapsular nerve group block (PENG block), and LIA. Regional nerve blocks, such as femoral nerve block (FNB) and PENG block, have demonstrated efficacy in reducing postoperative pain and opioid consumption while preserving quadriceps muscle strength, thereby promoting rapid postoperative recovery. The PENG block, in particular, has shown promise as a preferred nerve block option for THA due to its ability to effectively block multiple nerves supplying the hip joint without affecting lower limb muscle strength. LIA, involving the infiltration of a high-volume local anesthetic solution around the joint capsule and surgical incision, has also proven to be a simple, cost-effective, and efficacious method for acute pain control after THA. Its analgesic effects are comparable to those of intrathecal morphine injection or peripheral nerve blocks, and it does not affect lower limb muscle strength. Combining LIA with nerve blocks such as PENG and FNB can further enhance multimodal analgesia. However, there is currently no unified formula for the drug composition of LIA, and research on liposomal bupivacaine, a sustained-release formulation of bupivacaine, has yielded varying results regarding its benefits. Overall, current evidence supports the use of regional nerve blocks, particularly the PENG block, and LIA as effective analgesic methods for postoperative THA, with the potential for further optimization through combination therapies and standardized protocols.
Abstract: Total hip arthroplasty (THA) is a highly effective treatment for end-stage osteoarthritis and hip fractures, significantly enhancing patients' quality of life. However, substantial postoperative pain remains a challenge, potentially impeding rehabilitation, prolonging hospitalization, and increasing the risk of chronic pain and subsequent revision ...
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Case Report
Difficult Endotracheal Intubation Due to an Epiglottic Mass: A Case Report
Su Ying*
Issue:
Volume 13, Issue 2, December 2025
Pages:
89-92
Received:
6 August 2025
Accepted:
13 August 2025
Published:
18 August 2025
DOI:
10.11648/j.ijacm.20251302.15
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Abstract: Epiglottic masses may present as cystic, infectious, neoplastic, or systemic disease manifestations. Their size and location can lead to airway obstruction, increasing the difficulty of general anesthesia induction. Perioperative management for such patients requires meticulous planning to prevent sudden airway challenges post-anesthesia. Multidisciplinary collaboration (anesthesiology and otolaryngology) and the use of visualization devices (e.g., video laryngoscopy) are critical for ensuring airway safety. We described the anesthesia management for a 69-year-old male with a glottic mass. Laryngoscopy and CT revealed a 2.7×2.0 cm cauliflower-like mass on the lingual surface of the epiglottis (squamous high-grade intraepithelial neoplasia/carcinoma in situ). After comprehensive evaluation of the airway and perioperative drug interactions, appropriate sedatives, analgesics, and muscle relaxants were selected. The patient successfully completed the surgery and was discharged. The selection of the anesthesia intubation approach for epiglottic masses should be predicated on the size and location of the masses, along with the patient's specific circumstances. This case underscores the significance that conducting a thorough preoperative assessment of the patient prior to surgery and implementing multidisciplinary cooperation in light of the patient's condition can substantially mitigate anesthesia - related risks. Video laryngoscopy-assisted endotracheal intubation is the preferred method for protecting lingual epiglottic masses, minimizing tumor injury risks. However, its successful and safe implementation requires collaboration between experienced anesthesiology and otolaryngology teams.
Abstract: Epiglottic masses may present as cystic, infectious, neoplastic, or systemic disease manifestations. Their size and location can lead to airway obstruction, increasing the difficulty of general anesthesia induction. Perioperative management for such patients requires meticulous planning to prevent sudden airway challenges post-anesthesia. Multidisc...
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Case Report
Application of Perioperative Transesophageal Echocardiography in Resection of Pulmonary Artery Sarcoma: A Case Report
Yang Chen,
Yang Jing*
Issue:
Volume 13, Issue 2, December 2025
Pages:
93-97
Received:
31 July 2025
Accepted:
11 August 2025
Published:
18 August 2025
DOI:
10.11648/j.ijacm.20251302.16
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Views:
Abstract: Pulmonary artery sarcoma (PAS) is an extremely rare and aggressive malignancy, often misdiagnosed as pulmonary thromboembolism due to overlapping clinical presentations. This case report describes a 35-year-old female with progressive dyspnea and syncope, initially managed as pulmonary embolism. Despite anticoagulation therapy, persistent intracardiac masses were identified, prompting urgent surgical intervention. Transesophageal echocardiography (TEE) played a pivotal role intraoperatively, revealing a large mobile mass obstructing the pulmonary artery and causing hemodynamic instability. Following cardiac arrest, emergency surgery with extracorporeal circulation support was performed. Postoperative TEE demonstrated reduced mass size and improved pulmonary blood flow, although histopathological examination confirmed malignant carcinosarcoma. Unfortunately, the patient experienced recurrent syncopal episodes post-discharge and succumbed to the illness despite resuscitation efforts. This case highlights the diagnostic challenges of PAS and the indispensable role of TEE throughout the perioperative period. TEE provides real-time hemodynamic monitoring, precise tumor localization, and assessment of right ventricular function, facilitating timely surgical decisions. Intraoperatively, TEE continuously monitors for sudden hemodynamic changes, such as right ventricular outflow tract obstruction, and guides therapeutic interventions. Postoperatively, TEE aids in evaluating surgical outcomes, detecting residual masses or complications, and informing postoperative management strategies. Multi-planar TEE assessment, especially the ME gastric view, is crucial for comprehensive evaluation. This case underscores the importance of integrating TEE into the management of PAS to optimize patient outcomes.
Abstract: Pulmonary artery sarcoma (PAS) is an extremely rare and aggressive malignancy, often misdiagnosed as pulmonary thromboembolism due to overlapping clinical presentations. This case report describes a 35-year-old female with progressive dyspnea and syncope, initially managed as pulmonary embolism. Despite anticoagulation therapy, persistent intracard...
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